Magnetic flux flow and superconductor stabilization Quarterly report, 1 Jan. - 31 Mar. 1968

Magnetic flux flow and stability of superconducting niobium titanium strip

a randomized double blind placebo controlled phase 1 study of multiple ascending doses of subcutaneous m1095 an anti interleukin 17a f nanobody in moderate to severe psoriasis

Background Interleukin 17 is involved in the pathogenesis of psoriasis, a chronic debilitating disease. Objectives To evaluate the safety/tolerability, immunogenicity, pharmacokinetics/pharmacodynamics, and efficacy of M1095, an anti–interleukin 17A/F nanobody, in moderate-to-severe plaque psoriasis. Methods This multicenter, double-blind, placebo-controlled dose escalation phase 1 study randomized 44 patients 4:1 to treatment with subcutaneous M1095 (30, 60, 120, or 240 mg) or placebo biweekly for 6 weeks, in 4 ascending dose cohorts. Results The most frequent treatment-emergent adverse events with M1095 were pruritus (n = 4) and headache (n = 3); 2 patients withdrew owing to adverse events (injection site reaction and elevated liver enzyme levels). The terminal half-life of M1095 was 11 to 12 days. The area under the curve/maximum concentration was dose proportional. Of 10 M1095-treated patients positive for antidrug antibodies, 5 showed treatment-emergent antidrug antibody responses. There was no effect on M1095 exposure. Marked decreases in psoriasis inflammatory markers were observed with M1095. By day 85, 100% and 56% of patients receiving M1095, 240 mg, achieved psoriasis area and severity index 90 and 100, respectively. Improvements in static Physician's Global Assessment and affected body surface area were also seen. Limitations Interpretation of efficacy data is limited by the small sample size. Conclusion Multiple subcutaneous doses of M1095 showed a favorable safety profile with dose-dependent improvements in psoriasis

Magnetic flux flow and superconductor stabilization Quarterly report, Apr. 1 - Jun. 30, 1967

Magnetic flux flow and superconductor stabilizatio

Threshold Laws for the Break-up of Atomic Particles into Several Charged Fragments

The processes with three or more charged particles in the final state exhibit particular threshold behavior, as inferred by the famous Wannier law for (2e + ion) system. We formulate a general solution which determines the threshold behavior of the cross section for multiple fragmentation. Applications to several systems of particular importance with three, four and five leptons (electrons and positrons) in the field of charged core; and two pairs of identical particles with opposite charges are presented. New threshold exponents for these systems are predicted, while some previously suggested threshold laws are revised.Comment: 40 pages, Revtex, scheduled for the July issue of Phys.Rev.A (1998

Evolution and Impact of Bars over the Last Eight Billion Years: Early Results from GEMS

Bars drive the dynamical evolution of disk galaxies by redistributing mass and angular momentum, and they are ubiquitous in present-day spirals. Early studies of the Hubble Deep Field reported a dramatic decline in the rest-frame optical bar fraction f_opt to below 5% at redshifts z>0.7, implying that disks at these epochs are fundamentally different from present-day spirals. The GEMS bar project, based on ~8300 galaxies with HST-based morphologies and accurate redshifts over the range 0.2-1.1, aims at constraining the evolution and impact of bars over the last 8 Gyr. We present early results indicating that f_opt remains nearly constant at ~30% over the range z=0.2-1.1,corresponding to lookback times of ~2.5-8 Gyr. The bars detected at z>0.6 are primarily strong with ellipticities of 0.4-0.8. Remarkably, the bar fraction and range of bar sizes observed at z>0.6 appear to be comparable to the values measured in the local Universe for bars of corresponding strengths. Implications for bar evolution models are discussed.Comment: Submitted June 25, 2004. 10 pages 5 figures. To appear in Penetrating Bars through Masks of Cosmic Dust: The Hubble Tuning Fork Strikes a New Note, eds. D. Block, K. Freeman, R. Groess, I. Puerari, & E.K. Block (Dordrecht: Kluwer), in pres

Anionic Photofragmentation of CO: A Selective Probe of Core-Level Resonances

Anion-yield spectroscopy using x rays is shown to be a selective probe of molecular core-level processes, providing unique experimental verification of shape resonances. For CO, partial anion and cation yields are presented for photon energies near the C K edge. The O- yield exhibits features above threshold related only to doubly excited states, in contrast to cation yields which also exhibit pronounced structure due to the well-known σ* shape resonance. Because the shape resonance is completely suppressed for O-, anion spectroscopy thus constitutes a highly selective probe, yielding information unobtainable with absorption or electron spectroscopy

Military objectives in cyber warfare

This Chapter discusses the possible problems arising from the application of the principle of distinction under the law of armed conflict to cyber attacks. It first identifies when cyber attacks qualify as ‘attacks’ under the law of armed conflict and then examines the two elements of the definition of ‘military objective’ contained in Article 52(2) of the 1977 Protocol I additional to the 1949 Geneva Conventions on the Protection of Victims of War. The Chapter concludes that this definition is flexible enough to apply in the cyber context without significant problems and that none of the challenges that characterize cyber attacks hinders the application of the principle of distinction